Tumor-Associated Macrophages and TNF-α May Help Rescue Treatment Efficacy in Ovarian Cancer

Ricardo Coelho, MD and Senior Postdoctoral Researcher at Universitätsspital Basel, discusses how chemotherapy-induced changes in the tumor microenvironment may be leveraged to improve treatment efficacy in high-grade serous ovarian cancer. He presents preclinical findings showing that sequential treatment with chemotherapy and a SMAC mimetic drives TNF-α-dependent tumor cell killing, while tumor-associated macrophages and TNF-α emerge as potential predictive biomarkers for combination treatment response.