EHA 2019: Prognostic significance of SAMHD1 expression in diffuse large b-cell lymphoma

Georgios Rassidakis | EHA 2019 | Juni 18, 2019

Speaker: Georgios Rassidakis

The SAM domain and HD domain 1 (SAMHD1) protein is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, which has been initially described to restrict human immunodeficiency virus type 1 (HIV-1) in the immune cells. 


This study shows that SAMHD1 is expressed in approximately half of de novo diffuse large B-cell Lymphomas at a variable level and correlates with cell of origin (GC), biomarkers of tumor aggressiveness (eg MYC, proliferation) and clinical outcome.