There Is a Lack of Data on the Effect of Dose Optimization

In practice, dose adjustments are frequently implemented to enhance treatment efficacy. However, robust evidence supporting the effectiveness of these modifications is often lacking, says Dr. Peter Bossuyt in this MEDtalk. At ECCO 2025, Dr. Bossuyt presented the REScUE study, which examined ustekinumab dose optimization in Crohn’s disease patients experiencing secondary loss of response.