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Predicting a mutation in the melanoma predisposing gene CDKN2A

Many melanoma cases show a familial association. The most important predisposing gene so far characterized is CDKN2A. The risk of pancreatic cancer has been especially high in Dutch and Swedish mutation-carrying families. Dutch and Swedish researchers have developed a risk score (CM-score) for predicting the presence of a CDKN2A mutation has been developed.

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